Basic science evidence suggests that chiropractic adjustments modulate immune mediators in healthy individuals in the short term and cortisol levels in symptomatic and asymptomatic individuals. However, clinically relevant research has not yet been done. The purpose of this study is to determine whether there is an association between regular chiropractic care and immune status. Two groups, one that has received regular chiropractic care over the past 12 months and one that has not, will complete self-reporting questionnaires and blood analyses relevant to assessing their immune status. The results of this observational case-control study will help inform the design of future experimental trials.
Grant Value: $39,898
Chief Investigator: Dr Heidi Haavik – New Zealand College of Chiropractic
Status: Completed
Researcher Updates:
- April 2026
First paper has now been published, and more are being prepared for submission - January 2025
Manuscripts have been completed and submitted for publication. - July 2024
Data has been collected and analysed. The manuscript is currently being written with the plan to submit by the end of 2024. - July 2023
Ethics has been approved and data collection is now underway.
Publications:
- PLOS ONE, Volume 20, December 2025.
Amjad I, Niazi IK, Kumari N, Ghani U, Rashid U, Duarte FCK and Holt K (2025)Â The effects of 12 weeks of chiropractic spinal adjustments on physiological biomarkers in adults: A pragmatic randomized controlled trial.

