Superbugs That Don’t Respond to Antibiotics Now a Global Health Threat.

 Story at a Glance.

  • A global health crisis has been declared by the United Nations regarding bacteria and viruses that are now resistant to antibiotics.
  • Overuse of antibiotics in animals and humans has developed resistant strains of viruses, bacteria, parasites and fungi.
  • This has far reaching consequences both to the success of medical procedures, in both humans and animals, and to the cost of healthcare globally.

The United Nations called a crisis meeting in New York on the 21st of September 2016, to address what has become a global emergency – antibiotic resistance. Viruses, bacteria, fungi and parasites, no longer responding to antibiotics that used to stop them.

It’s called Antimicrobial Resistance (AMR).

The World Health organisation calls them superbugs: micro-organisms that adapt and change when exposed to antibiotics. In other words, the infection persists in the individual because it is no longer affected by the medicine.

The WHO is worried that this is bad news for the very health of humanity. The antibiotic resistance isn’t just from humans over-consuming antibiotics, it’s because the animals we farm and subsequently consume, are over-consuming them too. Farmed animals aren’t simply given antibiotics when they’re sick, they are fed a steady diet of drugs as a preventative measure, to stop them getting sick to start with. That’s like you and me waking up in the morning and knocking back a capsule of penicillin just in case we end up catching a cold that week. Every facet of our farming culture, globally, has been overexposed to antibiotics; and now, they’re not working anymore.

It’s a sobering thought. If we have a global spread of infections that are resistant to antimicrobial medicines, we will be looking at infections in people and animals that medicine can no longer treat.

And, this is not a third world issue. Economic status does not protect countries from AMR. And it’s not limited to whether you live in the city or on a farm. AMR is sweeping the world, and infections that were once responsive, such as HIV, TB, Typhoid, chlamydia, gonorrhoea, syphilis, malaria, pneumonia and urinary tract infections….no longer are.

The World Health Organisation’s report on Antimicrobial Resistance had this to say about it,

“Klebsiella pneumonia, a common intestinal bacteria that can cause life-threatening infections has spread to all regions of the world.”

K.pneumoniae is now resistant to what’s referred to as the last resort treatment – carbapenem antibiotics. This bacteria is the type of bacteria we commonly see in hospital-acquired infections such as pneumonia, bloodstream infections, and infections in newborns and intensive-care unit patients.

“Patients with infections caused by drug-resistant bacteria are at increased risk of worse clinical outcomes and death, and consume more health-care resources than patients infected with non-resistant strains of the same bacteria.”

So how did this happen? How do antibiotics that were once so successful become so impotent?

Well to start with, let’s just get a few things cleared up. It’s not the people that become resistant to the antibiotic; it’s the virus or bacteria itself.

Tony Mazzulli, an associate professor at the University of Toronto medical school and deputy chief microbiologist and infectious diseases specialist at Mount Sinai Hospital in Toronto, explains.

“The concept of antibiotic immunity is a misnomer that can lead people to believe that they may become “immune” or “resistant” to an antibiotic if they take it too frequently or inappropriately. This notion stems from a misunderstanding in the general public of the concept of antibiotic resistance.”

Bacteria have been around for thousands of years. And like any organism they adapt. What they are very good at is adapting to their environment, most specifically, hostile environments. They’ve learnt resistance mechanisms, tools on how to survive. And one of those tools has been to develop a resistance to antibiotics.

We take antibiotics to kill bacteria. If we take enough of them, that is if we expose enough bacteria to antibiotics, the only ones that are left, are the ones that are resistant to the antibiotics. They are the bacteria that continue to grow and flourish. It’s kind of like Darwin’s survival of the fittest theory. If we kill off all the bacteria that are susceptible to antibiotics, only the strongest and fittest bacteria survive. We call these bacteria AMR bacteria. Or superbugs.

Now if these AMR bacteria start to spread from animal to animal, you end up with a legion of new, better, stronger bacteria which becomes the new norm. That means the bacteria that used to cause malaria, no longer exists and is superseded by the superbug version. Which means exposure and infection by the new, better equipped bacteria that is resistant to medicine’s only line of defence.

“New resistance mechanisms are emerging and spreading globally, threatening our ability to treat common infectious diseases, resulting in prolonged illness, disability, and death,” says the WHO report.

“Without effective antimicrobials for prevention and treatment of infections, medical procedures such as organ transplantation, cancer chemotherapy, diabetes management and major surgery (for example, caesarean sections or hip replacements) become very high risk.”

WHO says that it’s the misuse and overuse of antimicrobials that has accelerated the process, like taking antibiotics for viral infections like colds and flus or using antibiotics to make animals grow bigger.

“Antimicrobial resistant-microbes are found in people, animals, food, and the environment (in water, soil and air). They can spread between people and animals, and from person to person. Poor infection control, inadequate sanitary conditions and inappropriate food-handling encourage the spread of antimicrobial resistance,” notes the report.

In the end, it’s medical procedures that will no longer be able to be performed, it’s the rising cost of health care, the length of stays in hospital and the intensive care required, that will be most affected by this crisis.

There is now a requirement for global coordinated action to minimise the spread of antimicrobial resistance. AMR is a complex problem that is interconnected by many factors.  And as such is seen by the UN as a global threat, one that may outstrip the AIDS epidemic, the obesity crisis and Ebola.

It will be fascinating to see what the pharmaceutical / medical industry will do, in response. What will they develop as the new line of defence? Will healthier farming practices reduce the need for antibiotics?

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