Multiple sclerosis (MS) is an inflammatory autoimmune disease associated with an imbalance between pro- and anti-inflammatory cytokines resulting in a demyelinating and neurodegenerative disease. There is moderate quality evidence that spinal manipulation (SM) is better than control in influencing cytokine activity in asymptomatic individuals, but few studies have been completed in individuals with chronic inflammatory conditions. The objective of this project is to examine the immediate (1 SM treatment) and summative impact (8 SM treatments/4wks) on pro-inflammatory (IL-1β, IL-6, TNF-α) and anti-inflammatory (IL-4, IL-10) plasma cytokines 20 minutes and 2 hours post-SM in individuals diagnosed with neuroinflammatory relapsing-remitting MS (MS-RR).
Grant Value: $39,980
Chief Investigator: William R. Reed DC, PhD
Status: In Progress