Multiple sclerosis (MS) is an inflammatory autoimmune disease associated with an imbalance between pro- and anti-inflammatory cytokines resulting in a demyelinating and neurodegenerative disease. There is moderate quality evidence that spinal manipulation (SM) is better than control in influencing cytokine activity in asymptomatic individuals, but few studies have been completed in individuals with chronic inflammatory conditions. The objective of this project is to examine the immediate (1 SM treatment) and summative impact (8 SM treatments/4wks) on pro-inflammatory (IL-1β, IL-6, TNF-α) and anti-inflammatory (IL-4, IL-10) plasma cytokines 20 minutes and 2 hours post-SM in individuals diagnosed with neuroinflammatory relapsing-remitting MS (MS-RR).

Grant Value: $39,980
Chief Investigator: William R. Reed DC, PhD
Status: In Progress

Researcher Update:

  • May 2024
    Significant progress has been made in the last 6 months, with most participants having consented, enrolled, and completed the study. Project expected to be complete in December 2024, with publications/presentations to follow.
  • November 2024
    Project still in progress. Some delays have resulted from COVID and other challenges. Expected completion in December 2024.